Alternative mRNA processing sites decrease genetic variability while increasing functional diversity

Alternative mRNA processing sites decrease genetic variability while increasing functional diversity

Recent large-scale RNA sequencing efforts have revealed the extensive diversity of mRNA molecules produced from most eukaryotic coding genes, which arises from the usage of alternative, cryptic or non-canonical splicing and intronic polyadenylation sites. The prevailing view regarding the tremendous diversity of coding gene transcripts is that mRNA processing is a flexible and more-or-less nois...

Genetic Variability of Splicing Sites

Splicing sites provide unique statistics in human genome due to their large number and reasonably complete annotation. Analyses of the cumulative SNPs distribution in splicing sites reveal a few interesting observations. While a degree of the nucleotide conservation reflects on the SNPs density monotonically, no detectable changes in the SNPs frequencies spectrum were found. Semi-conserved nucl...

Microbial Diversity: Genetic Diversity Vs Functional Diversity

Diversity is the main descriptor of community structure and is a determining factor in the dynamics and function of ecological communities [1]. However, the latter implicitly differs based on the different types of organisms and their relative abundance within the community which is considered to be significant [2]. Research in microbial ecology focuses on the study of microbial community dynam...

Microbial Diversity: Genetic Diversity Vs Functional Diversity

Diversity is the main descriptor of community structure and is a determining factor in the dynamics and function of ecological communities [1]. However, the latter implicitly differs based on the different types of organisms and their relative abundance within the community which is considered to be significant [2]. Research in microbial ecology focuses on the study of microbial community dynam...

Increasing HIV-1 genetic diversity in Europe.